Lipid Disorder Education Program

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Sequestrant Alert

Five Questions to Ask Before Starting Sequestrants!

i) Are fasting triglycerides above 250 mg/dl?
Triglycerides will worsen by 10-50% with sequestrants!
Consider lowering triglycerides to below 200 mg/dl before using sequestrants.
ii) Is patient currently constipated?
It will only get worse!
Consider fiber, stool softeners, and/or mineral oil to treat the constipation.
iii) Is patient currently taking 3 or more other drugs?
Scheduling of sequestrants to separate them properly from other medications will be a problem.
iv) Is patient a previous sequestrant failure?
He/she will be unlikely to tolerate a rechallenge, but you might try a different sequestrant preparation (i.e. Questran Light instead of Questran).
v) Is the patient willing and able?
The patient must be cooperative to withstand initiation and maintenance of sequestrant therapy.


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