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Weiss, Harvey R. Ph.D.

Harvey R. Weiss, PhD

Professor of Neuroscience and Cell Biology

Phone: 732-235-4626
Fax: 732-235-5038
Email: hweiss@rwjms.rutgers.edu

Research Interests:

Changes in oxygen supply, consumption and blood brain barrier permeability during cerebral ischemia and reperfusion. Role of hypoxia inducible factor-1 and excitatory amino acids in this regard. Mechanisms to control cerebral oxygen consumption during autism.

Description:

In the heart, we are currently exploring the relationship between signal transduction and the control of local metabolism. We are focusing on the natriuretic peptide nitric oxide-cyclic GMP signal transduction system, which acts as a "brake" on myocardial function. This system exerts significant control of oxygen supply/consumption through direct effects on myocytes and vascular smooth muscle. We are attempting to determine the mechanisms through which this system operates and how problems like myocardial infarction and heart failure affect the responses to this system. For example, in failure, the activity of this system is increased but its effects are greatly reduced. We would like to correct this problem.

In the brain, excitatory amino acids, such as glutamate, increase cerebral oxygen consumption, while other amino acids reduced consumption. The relative importance of the various receptors in the control of cerebral metabolism is not known. Activation of these receptors also affects cerebral blood flow. How the relationship between cerebral oxygen supply and consumption is affected by these receptors is not known. We also wish to determine the importance of the various receptor subtypes in the control of cerebral metabolism during stroke and autism.

Publications:

Chi, O.Z., C. Hunter, X. Liu, S.K. Chokshi and H.R. Weiss. Effects of fentanyl pretreatment on regional cerebral blood flow in focal cerebral ischemia in rats. Pharmacol. 85:153-157, 2010.

Chi, O.Z., C. Hunter, X. Liu and H.R. Weiss. The effects of isoflurane pretreatment on cerebral blood flow, capillary permeability, and oxygen consumption in focal cerebral ischemia in rats. Anesth. Analg. 110:1412-1418, 2010.

Liu, X., C. Hunter, H.R. Weiss and O.Z. Chi. Effects of blockade of ionotropic glutamate receptors on blood-brain barrier disruption in focal cerebral ischemia. Neurol. Sci. 31:699-703, 2010.

Chi, O.Z., C. Hunter, X. Liu, Y. Chi and H.R. Weiss. Effects of GABAA receptor blockade on regional cerebral blood flow and blood-brain barrier disruption in focal cerebral ischemia. J. Neurol. Sci. 301:66-70, 2011.

Chi, O.Z., C. Hunter, X. Liu and H.R. Weiss. The effects of dexmedetomidine on regional cerebral blood flow and oxygen consumption during severe hemorrhagic hypotension in rats. Anesth. Analg. 113:349-355, 2011.

Chi, O.Z., S. Barsoum, J. Grayson, C. Hunter., X. Liu and H.R. Weiss. Effects of cannabinoid receptor agonist WIN 55,212-2 on blood-brain barrier disruption in focal cerebral ischemia in rats. Pharmacol. 89:333-338, 2012.

Weiss, H.R., X. Liu, P. Grewal and O. Z. Chi. Reduced effect of stimulation of AMPA receptors on cerebral O2 consumption in a rat model of autism. Neuropharmacol. 63:837-841, 2012.

Chi, O.Z., J. Grayson, S. Barsoum, C. Hunter, X. Liu and H.R. Weiss. Effects of a PDGFR-a antagonist imatinib on blood-brain barrier disruption in focal cerebral ischemia in younger and older rats. J. Neurol. Res. 2:127-133, 2012.

Staff:

Xia Liu, M.D., Instructor
Tao Tan , Graduate Student
Jason Luciano , Medical Student

Graduate Program Membership:

Physiology and Integrative Biology
Neuroscience
Biomedical Engineering

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