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Rasin, Mladen-Roko MD, PhD
Photograph of Mladen-Roko Rasin, MD, PhD

Associate Professor
MD, University of Zagreb School of Medicine, Zagreb, Croatia, 2002
PhD, University of Zagreb School of Natural Sciences, Zagreb, Croatia, 2006

Phone: 732-235-4553
Fax: 732-235-4029


Research Interest:
Research of our lab focuses on the timed posttranscriptional events controlling development of normal and lesioned neural stem cells and projection neurons of the cerebral cortex. In particular, our focus is on revealing the role of temporally defined posttranscriptional processing events in the developmental cellular processes that are regulated by neocortical RNA binding proteins under the guidance of timed morphogen and/or trophic signals from distant structures, such as thalamus. Finally, we are revealing how these intricate processes are disrupted after the transient intrauterine ischemia, which often leads into a spectrum of postnatal child and life-long disorders, including mental retardation and cerebral palsy.

Publications: For complete list PubMed

  • Kwan KY, Lam MMS, Johnson MB, Dube U, Shim S, Rasin MR, Sousa AMM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostovic I, Judas M, Sestan N (2012). Species-Dependent Posttranscriptional Regulation of NOS1 by FMRP in the Developing Cerebral Cortex. Cell. 149:899-911.
  • Petanjek, Z., Judas, M., Simic, G., Rasin, MR, Uylings, H.B.M., Rakic P., Kostovic I. (2011). Extraordinary neoteny of synaptic spines in the human prefrontal cortex. PNAS USA. 108:13281-13286.
  • Thompson K, DiBona VL, Dubey A, Crockett DP, Rasin MR. (2010). Acute adaptive responses of central sensorimotor neurons after spinal cord injury. Transl. Neurosci. 1:268-278.
  • Fertuzinhos S, Krsnik Z, Kawasawa YI, Rasin MR, Kwan KY, Chen JG, Judas M, Hayashi M, Sestan N. (2009) Selective depletion of molecularly defined cortical interneurons in human holoprosencephaly with severe striatal hypoplasia. Cereb Cortex. 19:2196-2207.
  • Stillman AA, Krsnik Z, Sun J, Rasin MR, State MW, Sestan N, Louvi A. (2009) Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. J Comp Neurol. 513:21-37.
  • Rasin, M.R., Gazula, V.R., Breunig, J.B., Kwan, K.Y., Li, H.S., Liu-Chen, S., Jan, Y.N., Rakic, P., Sestan, N. (2007). Numb and Numbl are required for maintenance of cadherin based adhesion and polarity of neural progenitors. Nature Neurosci. 10:819-827.
  • Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M.R., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., Jan, Y.N. (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell. 127:1253-1264.
  • Smith, K.M., Ohkubo, Y., Maragnoli, M.E., Rasin, M.R., Schwartz, M.L., Sestan, N., Vaccarino, F.M. (2006). Midline radial glia translocation and corpus callosum formation require Fgf signaling. Nature Neurosci:9:787-797.
  • Chen, J.G.*, Rasin, M.R.*, Kwan, K.Y., Sestan, N. (2005). Zfp312 is required for subcortical projections and dendritic morphology of deep layer pyramidal neurons of the cerebral cortex. PNAS USA 102:17792-17797.
  • Abelson, J.F., Kwan, K.Y., O'roak, B.J., Baek, D.Y., Stillman, A.A., Morgan, T.M., Mathews, C.A., Pauls, D.L., Rasin, M.R., Gunel, M., Davis, N.R., Ercan-Sencicek, A.G., Guez, D.H., Spertus, J.A., Leckman, J.F., Dure, L.S. 4th, Kurlan, R., Singer, H.S., Gilbert, D.L., Farhi, A., Louvi, A., Lifton, R.P., Sestan, N., State, M.W. (2005). Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science. 310:317-320.

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