Lectures by Invitation

MMHCC Steering Committee Meeting, Los Angeles, CA

Keynote Speaker, Homeobox Workshop and Tissue Remodeling: Focus on Mammary Gland Workshop, Bethesda, MD

Co-Chair Minisymposium, American Association for Cancer Research Annual Meeting, Orlando, FL

3rd NIH Conference on Holoprosencephaly, Bethesda, MD

Johns Hopkins University, Baltimore, MD

American Society of Andrology 29th Annual Meeting,

Chair, Prostate Cancer Charitable Trust, "Fundamental and Prostate Cancer Biology Session," New York, NY

Mouse Models of Human Cancer Consortium Steering Committee Meeting, Washington DC

Symposium on hormone-related malignancies, University of Colorado Cancer Center, Aurora, CO

Karmanos Cancer Institute, Wayne University Grand Rounds, Detroit, MI

Session Chair, AACR Special Conference: Basic, Translational, and Clinical Advances in Prostate Cancer, Bonita Springs, FL

Sackler School of Graduate Biomedical Sciences, Tufts University Boston, MA

St. Jude Children's Research Hospital, Memphis, TN

Mouse Models of Human Cancer Consortium Steering Committee Meeting, Nashville, TN

UCSF, Seminars in Biomedical Science, San Francisco, CA

Education

The Division trained several post-doctoral and pre-doctoral fellows. The success is this area is evident by the accomplishment of competitive training grants as well as high-caliber publications. In addition, undergraduate students have gone on to medical school.

Research

Characterization of Msx1 in murine embryogenesis; Principal Investigator; NIH

Roles of Nkx3.1 in prostate development and cancer; Principal Investigator; NIH

A mouse model for prostate cancer; Principal Investigator; NIH, MMHC Consortium

Publications

Abate - Shen, C. (2003). Homeobox genes and cancer: New OCTaves for an old tune. Cancer Cell 4: 329-330.

Shen, M. M., and Abate-Shen, C. (2003). Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Dev. Dyn. 228: 767-778.

Berman, D. M., Desai, N., Wang, X., Karhadkar, S. S., Reynon, M., Abate-Shen, C ., Beachy, P. A., and Shen, M. M. (2004) Prostate defects of Sonic hedgehog mutant mice are a consequence of androgen insufficiency. Dev. Biol . , 267: 387-398.

Lee, H., Habas, R., and Abate-Shen, C . (2004) Msx1 cooperates with histone H1b for inhibition of transcription repression and myogenesis. Science, 304:1675-1678.

Gao, H., Ouyang, O., Banach-Petrosky. W., Borowsky. A.D., Lin Y., Kim. M., Lee, H., Sun, X., Shih, W.-J., Cardiff, R.D., Shen, M.M., and Abate-Shen, C . (2004) A critical role for p27 kip1 gene dosage in a mouse model of prostate carcinogenesis. Proc. Natl. Acad. Sci. USA , 101: 17204-17209.

Kuzmichev, A., Margueron, R., Vaquero, A., Preissner, T. S., Scher, M., Kirmizis, A., Ouyang, X., Brockdorff, N., Abate-Shen, C. , Farnham, P., and Reinberg, D. (2005) The composition and histone substrates of polycomb repressive group complexes change during differentiation and cancer. Proc. Natl. Acad. Sci. USA . 102:1859-1864.

Ouyang, X., DeWeese, T., Nelson, W.G., and Abate-Shen, C . (2005) Loss-of-function of Nkx3.1 promotes increased oxidative damage in prostate carcinogenesis. Cancer Research in press.

Lee, H., Quinn, J.C., Economides, K.D., Swiss, V.A., Camacho, M.M., and Abate-Shen, C . (2005) PIAS1 confers DNA binding specificity on the Msx1 homeoprotein. Cell in revision.