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Faculty

Leroy F. Liu, Ph.D.

Publications
1. Hars, E. S., Qi, H., Ryazanov, A. G., Jin, S., Cai, L., Hu, C. and Liu, L. F. “Autophagy regulates aging in C. elgans”, Autophagy, 3, 93-95 (2007).

2. Tsang, C. K., Qi, H., Liu, L. F. and Zheng, X. F. S. “Targeting Mammalian Target of Rapamycin (mTOR) for Health and Diseases”. Drug Discovery Today, 12:112-124 (2007).

3. Azarova, A. M., Lyu, Y. L., Lin, C.-P., Tsai,Y.-C., Lau, J. Y.-N., Wang, J. C. and Liu, L. F. “Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies” Proc. Natl. Acad. Sci. USA, 104: 11014-11019 (2007).

4. Meiners, S., Ahmed, I., Azarova, A., Lin, C.-P., Lyu, Y.-L., and Liu, L. F. “Role of DNA Topoisomerase IIbeta in Neurite Outgrowth, Brain Res. 1154:50-60 (2007)

5. Lyu, Y. L., Kerrigan, J. E., Lin, C.-P., Azarova, A., Tsai, Y.-C. and
Liu, L. F. "Topoisomerase IIb-Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane” Cancer Res. 67: 8839-8846 (2007).

6. Zhang, Y., Qi, H., Taylor, R., Xu, W., Liu, L. F. and Jin, S. “The Role of Autophagy in Mitochondria Maintenance: Characterization of Mitochondrial Functions in Autophagy-Deficient S. cerevisiae Strains”. Autophagy. 3: 17404498 (2007)

7. Tsai, Y.-C., Qi, H. and Liu, L. F. “Protection of DNA Ends by Telomeric 3’ G-Tail Sequences” J. Biol. Chem. 282:18786-92 (2007).

8. Fu, X., Wan, S., Lyu, Y. L., Liu, L. F. and Qi, H. “Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation” PLoS ONE. 3:e2009 (2008).

9. Desai, S. D., Wood, L. J., Tsai, Y.-C., Hsieh, T. S., Marks, J. R., Scott, G. L., Giovanella, B. C. and Liu, L. F. “ISG15 as a Novel Tumor Biomarker for Drug Sensitivity” Molecular Cancer Therapeutics, 7:1430-1439 (2008).

10. Satyanarayana, M., Rzuczek, S. G., LaVoie, E. J., Pilch, D. S., Liu, A. Liu, L. F. and Rice, J. E., “Ring-Closing Metathesis for the Synthesis of a Highly G-Quadruplex Selective Macrocyclic Hexaoxazole Having Enhanced Cytotoxic Potency”, Bioorganic and Medicinal Chemistry Letters, 18: 3802-3804 (2008).

11. Lin, C.-P., Ban, Y., Lyu, Y. L., Desai, S. D. and Liu, L. F. “A ubiquitin-proteasome pathway for the repair of Top1-DNA covalent complexes” J. Biol. Chem. 283:21074-21083 (2008).

12. Klionsky, D., Abeliovich, H., Agostinis, P., et al. “Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes”. Autophagy 4: 151-175 (2008).

13. Qi, H., Lin, C.-P., Fu, X., Chen, Y., Zheng, X. S. F., Lau, J. Y.-N. and Liu, L. F. TOR Regulates Telomere-Initiated Cell Death in Budding Yeast, PLoS ONE, 3(10):e3520. (2008).

14. Feng, W, Satyanarayana, M, Cheng, L, Liu, A, Tsai, YC, Liu, L. F. and Lavoie, E. J. “Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents” Bioorg Med Chem. 16(20):9295-301. (2008).

15. Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, LaVoie EJ. 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.Bioorg Med Chem. 17:2877-85 (2009).

16. Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, LaVoie EJ. Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide. Eur J Med Chem. 44:3433-8 (2009).

17. Sharma L, Tsai YC, Liu AA, Liu LF, LaVoie EJ. Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones. Eur J Med Chem. 44:1471-6 (2009).

18. Tsai YC, Qi H, Lin CP, Lin RK, Kerrigan JE, Rzuczek SG, Lavoie EJ, Rice JE, Pilch DS, Lyu YL, Liu LF. A G-quadruplex stabilizer induces M phase cell cycle arrest. J. Biol. Chem. 284:22535-43 (2009).

19. Chao-Po Lin, C.-P., Ban, Y., Lyu,Y. L. and Leroy F. Liu. Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double-strand breaks at arrested replication forks. J. Biol. Chem. 284:28082-92 (2009).