Vasily M. Studitsky, Ph.D.
All eukaryotic DNA is tightly condensed within small nuclei in nucleoprotein complexes called chromatin. It has become clear that chromatin is an ultimate player in eukaryotic transcription and therefore mechanisms involved in eukaryotic transcription and its regulation should be analyzed in context of properly assembled chromatin. Currently our research is developing in the following primary directions:
• Analysis of the mechanisms of transcript elongation through chromatin and its regulation.
Since defects in gene regulation are leading causes of cancers and other human deseases, our research has direct implications for medicine. There are also very direct connections between players involved in chromatin remodeling and in cancerogenesis, as well as between numerous human diseases and transcript elongation.