Frederick H. Silver , Ph.D.
Department of Pathology and Laboratory Medicine
Department of Pathology and Laboratory Medicine
Robert Wood Johnson Medical School
675 Hoes Lane, R204
Piscataway, New Jersey 08854
Biomaterials, Biomechanics, Mechanotransduction and Medical Devices
Extracellular matrix (ECM) is found in both vertebrates and invertebrates and forms the structural scaffold of all tissues and
organs. The components of ECM include collagen fibers, proteoglycans, elastic fibers and cells. My laboratory is interested in
understanding how these components are assembled into multifunctional tissues that allow mammals to locomote, heal when
wounded and store energy through mechanotransduction. Our studies focus on the relationship between structure and
properties of ECMs and the use of tissue engineered ECMs as implants. We are also interested in changes in
mechanotransduction with age that may lead to impaired healing and disease.
B.S. Chemical Engineering
Massachusetts Institute of Technology
Ph.D., Polymer Science & Engineering
Thesis: Blood Compatibility of Collagen-Glycosaminoglycan Composites
Massachusetts General Hospital
- Landis, W.J., and Silver, F.H. 2009. Mineral deposition in the extracellular matrices of
vertebrate tissues: identification of possible apatite nucleation sites on type I
collagen. Cells Tissues Organs. 2009;189(1-4):20-4.
- Seehra, G.P., and Silver, F.H. 2006. Viscoelastic properties of acid- and alkaline-treated
human dermis: a correlation between total surface charge and elastic modulus.
Skin Res Technol. 2006 Aug;12(3):190-8.
- Freeman, J.W., and Silver, F.H. 2005. The effects of prestrain and collagen fibril alignment
on in vitro mineralization of self-assembled collagen fibers. Connect Tissue Res.
- Silver, F.H., Bradica, G., and Tria, A. 2004. Do changes in the mechanical properties of
articular cartilage promote catabolic destruction of cartilage and
osteoarthritis? Matrix Biol. Nov;23(7):467-76.
- Freeman, J.W., and Silver, F.H. 2004. Analysis of mineral deposition in turkey tendons and
self-assembled collagen fibers using mechanical techniques. Connect Tissue Res.
- Freeman, J.W., and Silver, F.H. 2004. Elastic energy storage in unmineralized and mineralized
extracellular matrices (ECMs): a comparison between molecular modeling and
experimental measurements. J. Theor Biol. Aug 7;229(3):371-81.
- Silver, F.H., and Siperko, L.M. 2003. Mechanosensing and mechanochemical transduction: how is
mechanical energy sensed and converted into chemical energy in an extracellular
matrix? Crit Rev Biomed Eng. 31(4):255-331.
- Silver, F.H., and Bradica, G. 2002. Mechanobiology of cartilage: how do internal and
external stresses affect mechanochemical transduction and elastic energy storage?
Biomech Model Mechanobiol. Dec;1(3):219-38.
- Silver, F.H., DeVore, D., and Siperko, L.M. 2003. Invited Review: Role of mechanophysiology in
aging of ECM: effects of changes in mechanochemical transduction. J Appl Physiol.
- Silver, F.H., Freeman, J.W., and Seehra GP. 2003. Collagen self-assembly and the development
of tendon mechanical properties. J Biomech. 36(10):1529-53.
PubMed PMID: 14499302.
- Silver, F.H., Snowhill, P.B., and Foran, D.J. 2003. Mechanical behavior of vessel wall: a
comparative study of aorta, vena cava, and carotid artery. Ann Biomed Eng.
Jul-Aug;31(7):793-803. PubMed PMID: 12971612.
- Silver, F.H., Ebrahimi, A., and Snowhill, P.B. 2002. Viscoelastic properties of self-assembled
type I collagen fibers: molecular basis of elastic and viscous behaviors. Connect
Tissue Res. 43(4):569-80.
- Silver, F.H., Siperko, L.M., and Seehra, G.P. 2003. Mechanobiology of force transduction in
dermal tissue. Skin Res Technol. Feb;9(1):3-23.
- Landis, W.J., and Silver, F.H. 2002. The structure and function of normally mineralizing
avian tendons. Comp Biochem Physiol A Mol Integr Physiol.
- Silver, F.H., Horvath, I., and Foran DJ. 2002. Mechanical implications of the domain
structure of fiber-forming collagens: comparison of the molecular and fibrillar
flexibilities of the alpha1-chains found in types I-III collagen. J Theor Biol.
- Silver, F.H., Bradica, G., and Tria, A. 2001. Viscoelastic behavior of osteoarthritic
cartilage. Connect Tissue Res. 2001;42(3):223-33.
- Silver, F.H., Bradica, G., and Tria, A. 2002. Elastic energy storage in human articular
cartilage: estimation of the elastic modulus for type II collagen and changes
associated with osteoarthritis. Matrix Biol. 2002 Mar;21(2):129-37.
- Silver, F.H., Bradica, G., and Tria A. 2001. Relationship among biomechanical, biochemical,
and cellular changes associated with osteoarthritis. Crit Rev Biomed Eng.
- Silver, F.H., Horvath, I., and Foran, D.J. 2001. Viscoelasticity of the vessel wall: the role
of collagen and elastic fibers. Crit Rev Biomed Eng. 29(3):279-301.
- Silver, F.H., Christiansen, D., Snowhill, P.B., Chen, Y., and Landis WJ. 2000. The role of
mineral in the storage of elastic energy in turkey tendons. Biomacromolecules.